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| Huntingtin Linked To Neurogenesis | Fri, 13 Aug 2010 |
| New research finds that a protein that is often mutated in Huntington's disease (HD) plays an unexpected role in the process of neurogenesis. The research, published by Cell Press in the August 12 issue of the journal Neuron, provides new insight into HD pathology and has even broader implications for human health and disease... | |
| 'Clumping Proteins' In Neurodegeneration Common In Aging Process | Wed, 11 Aug 2010 |
| Many proteins that form insoluble clumps in the brains of people with Alzheimer's and other neurodegenerative diseases are also found in healthy individuals and clump together as a normal part of aging. According to a surprising new finding by researchers at the University of California, San Francisco, the discovery in the C... | |
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| Path That Stops Cells Consuming Themselves For Energy May Help Understanding Of Cancer And Aging | Mon, 02 Aug 2010 |
| US researchers have discovered a biological path that is essential for maintaining normal means of energy production in cells and may help us better understand metabolic processes in cancer and aging; cells use the path to shuttle calcium in and out of mitochondria, the tiny energy generators inside cells, and when it breaks down, cells consume themselves to get the energy they need... | |
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| Protease Associated With Damage After Stroke Implicated In Huntington's Toxicity | Fri, 30 Jul 2010 |
| A new study reveals that an enzyme linked with multiple disorders is also involved in the generation of toxic, neuron-killing protein fragments in Huntington's disease (HD). The research, published by Cell Press in the July 29 issue of Neuron, provides insight into Huntington's pathology and proposes new therapeutic strategies for this devastating incurable disease... | |
| Discovery Provides New Hope For Huntington Disease Treatment | Thu, 29 Jul 2010 |
| Australian scientists have identified the behaviour of the mutant protein 'huntingtin' which leads to the fatal Huntington's disease providing potential targets to treat the disease, a University of Melbourne study reveals. Huntington's disease is a genetic disease with no cure, characterized by a steady decline in motor control and the dysfunction and death of brain cells... | |
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| Every Action Has A Beginning And An End (And It's All In Your Brain) | Thu, 22 Jul 2010 |
| Rui Costa, Principal Investigator of the Champalimaud Neuroscience Programme at the Instituto Gulbenkian de Ciência (Portugal), and Xin Jin, of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health (USA), describe in the latest issue of the journal Nature, that the activity of certain neurons in the brain can signal the initiation and terminatio... | |
| New PBT2 Data In 2010 Hot Topics Session At International Conference On Alzheimer's Disease | Fri, 02 Jul 2010 |
| Prana Biotechnology Limited (NASDAQ: PRAN) (ASX: PBT) announced that its Head of Research, Assoc. Prof. Robert Cherny, will present new data on PBT2, the Company's lead compound in development for Alzheimer's disease, at the Hot Topics Therapeutics/Intervention session on July 14th at the International Conference of Alzheimer's Disease (ICAD) in Honolulu... | |
| Prevalence Of Huntington's Disease Much Higher Than Estimated | Wed, 30 Jun 2010 |
| Huntington's disease (HD) is much more common in the UK than current estimates suggest, according to a new Comment published in the peer-reviewed medical journal The Lancet. The Comment was written by Professor Sir Michael Rawlins, Chairman of the UK National Institute for Health and Clinical Excellence (NICE)... | |
| Abnormal Protein Makes Huntington's Disease Patients Sick | Wed, 16 Jun 2010 |
| An aggregating protein causes many of the symptoms of Huntington's disease, an incurable and frequently fatal brain disorder. Mosaic winner Ahmad Aziz discovered that the abnormal protein also aggregates in the hypothalamus, the part of the brain that regulates the autonomic nervous system and the endocrine system... | |
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| In Huntington's Disease Ku70 Shown To Be Critical Regulator Of DNA Damage | Tue, 04 May 2010 |
| Ku70, a component of the DNA repair complex, is shown to be a new critical player in the DNA damage-linked pathologies of Huntington's disease (HD), according to a study in the May 3 issue of the Journal of Cell Biology. DNA repair defends against naturally occurring or disease-related DNA damage during the long lifespan of neurons... | |
| Small Molecules Mimicking Key Brain Growth Factor Identified By Study | Tue, 20 Apr 2010 |
| Stanford University School of Medicine researchers have identified several small molecules that mimic a key but cumbersome protein in the brain, a discovery that could open the door to new therapies for a variety of brain disorders. The protein, designated by the acronym BDNF, is known to be involved in important brain functions that include memory and learning... | |
| Huntington's Disease: Faulty Cleanup Process May Be Key Event In Cause | Tue, 13 Apr 2010 |
| In a step towards a possible treatment for Huntington's disease, scientists at Albert Einstein College of Medicine of Yeshiva University have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntington's disease. Their research is described in the April 11 online edition of Nature Neuroscience... | |
| Faulty Clean-up Process May Be Key Event In Huntington's Disease | Mon, 12 Apr 2010 |
| In a step towards a possible treatment for Huntington's disease, scientists at Albert Einstein College of Medicine of Yeshiva University have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntington's disease. Their research is described in the April 11 online edition of Nature Neuroscience... | |
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| Protecting The Brain From A Deadly Genetic Disease | Wed, 24 Feb 2010 |
| Huntington's disease (HD) is a cruel, hereditary condition that leads to severe physical and mental deterioration, psychiatric problems and eventually, death. Currently, there are no treatments to slow down or stop it. HD sufferers are born with the disease although they do not show symptoms until late in life... | |
| Drug Shows Promise For Huntington's Disease | Tue, 09 Feb 2010 |
| An early stage clinical trial of the experimental drug dimebon (latrepirdine) in people with Huntington's disease appears to be safe and may improve cognition. That is the conclusion of a study published in the Archives of Neurology... | |