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| Molecular Gatekeeper Of Arthritis Identified | Fri, 10 Sep 2010 |
| Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report in a study published in The Journal of Experimental Medicine. The newly discovered gatekeeper is a protein that determines the fate - survival or death - of damaging cells that mistakenly attack the body's own tissues and lead to autoimmune disorders such as arthritis... | |
| Lupus Research Institute-Funded Study Points To Increased Risk For Lupus In Men | Sat, 04 Sep 2010 |
| Lupus Research Institute-funded researcher Betty Tsao, PhD, at the University of California Los Angeles has discovered that humans - males in particular - with a variant form of the immune receptor gene "Toll Like Receptor 7 (TLR7)" are at increased risk of developing the autoimmune disease systemic lupus erythematosus (lupus)... | |
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| Study Identifies Genetic Variation Linked To Lupus In Asian Men | Wed, 25 Aug 2010 |
| Genes reside along long chains of DNA called chromosomes. UCLA researchers have found that a variation in a gene on the sex chromosome X may enhance an immune response that leads to lupus in men. Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women... | |
| Study Identifies Genetic Variation Linked To Lupus In Asian Men | Tue, 24 Aug 2010 |
| Genes reside along long chains of DNA called chromosomes. UCLA researchers have found that a variation in a gene on the sex chromosome X may enhance an immune response that leads to lupus in men. Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women... | |
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| Lupus Drug BenlystaŽ (belimumab) Priority Review Granted By FDA | Fri, 20 Aug 2010 |
| BenlystaŽ (belimumab), a potential treatment for systemic lupus erythematosus has been granted a priority review designation by the FDA (Food and Drug Administration, USA), which is granted to medications, that if approved, offer significant treatment advances or provide treatment when no proper therapy exists... | |
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| Black Women With SLE Develop Cardiovascular Disease At Early Age | Fri, 20 Aug 2010 |
| A recent study by researchers at Penn State College of Medicine found significant racial disparities in the age of systemic lupus erythematosus (SLE) patients at the time of hospital admission for cardiovascular disease (CVD) events and CVD-related death. Black women were youngest to both be admitted with CVD and to have an in-hospital death due to CVD... | |
| New Target For Treating Autoimmunity | Tue, 10 Aug 2010 |
| Autoimmune disorders, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), occur when an individual's immune system turns on other cells in the body. Inappropriate and excessive production of the soluble immune mediators IL-17 and IL-21 have been linked to several autoimmune disorders... | |
| New Drug Target For Immune Diseases Discovered | Wed, 04 Aug 2010 |
| Researchers from Mount Sinai School of Medicine have found a new mechanism that explains how certain immune cells are activated to create protective antibodies against infections or pathological antibodies such as those present in autoimmune diseases like lupus and rheumatoid arthritis. The research is published online in the September issue of Nature Immunology... | |
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| Oxidative And Nitrosative Stress Contribute To Lupus Disease Activity | Fri, 25 Jun 2010 |
| University of Texas Medical Branch researchers have uncovered an association between free radical-mediated reactions and the severity and progression of system lupus erythematosus (SLE). Higher levels of oxidative and nitrosative stress markers were found in SLE patients with greater disease activity suggesting a causal relationship... | |
| Clinical Differences In Systemic Lupus Erythmatosus Patients May Be Affected By Genealogy | Mon, 21 Jun 2010 |
| The effects of Systemic Lupus Erythematosus (SLE) may differ based on the individual patient's genealogical heritage, according to results of a new study presented at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy. In particular, the study reinforced differences in SLE phenotype found between Northern and Southern European subpopulations... | |
| Chinese Systemic Lupus Erythematosus Data Reveal Differences In Epidemiology Across Continents | Mon, 21 Jun 2010 |
| The Chinese Systemic Lupus Erythematosus (SLE) Treatment and Research Group (CSTAR) announced interim epidemiological information on SLE patients in China at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy. Robust data on SLE patients has been scarce to date; but now CSTAR provides the first online registry of this magnitude in China... | |
| Rheumatoid Arthritis And SLE Negatively Affect The Sex Lives Of Patients | Mon, 21 Jun 2010 |
| Systemic Lupus Erythematosus (SLE) patients from Brazil and Rheumatoid Arthritis (RA) patients from France report that their rheumatic conditions negatively affect their emotional relationships and sex lives, according to research presented at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy... | |
| The LFA To Report On The Latest News From The International Lupus Congress | Fri, 18 Jun 2010 |
| Representatives and staff from the Lupus Foundation of America (LFA) are headed to the International Lupus Congress, which will be held from June 24-27 in Vancouver, Canada. This triennial meeting brings together physicians and researchers to share the latest developments in lupus... | |
| NATURE Publishes New Dynavax Findings On Novel Role Of TLRs In Lupus | Thu, 17 Jun 2010 |
| Dynavax Technologies Corporation (NASDAQ: DVAX) today reported in NATURE new data that may explain the resistance of lupus patients to glucocorticoid treatment. In the June 16, 2010 issue of NATURE, Dynavax scientists show that activation of cells of the innate immune system by two key receptors, TLR7 and TLR9, can cause glucocorticoid resistance in lupus patients... | |
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